https://articles.mercola.com/sites/articles/archive/2021/12/12/why-is-metabolic-inflexibility-problematic.aspx

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While SARS-CoV-2 is a rampant virus that can cause severe problems in vulnerable individuals, the real pandemic — the underlying cause that makes people susceptible to complications from the infection in the first place — is poor metabolic health
Aside from old age, obesity has been identified as one of the primary risk factors for being hospitalized with COVID-19 — doubling the risk of hospitalization in patients under the age of 60 in one study
One hypothesis for why obesity is worsening COVID-19 has to do with the fact that obesity causes chronic inflammation. Having more proinflammatory cytokines in circulation increases your risk of experiencing a cytokine storm
Insulin resistance is another top risk factor for COVID-19 that worsens outcomes and increases your risk of death
There are five primary parameters of metabolic health: waist circumference, insulin sensitivity, blood pressure, and triglyceride and HDL levels. Having three or more abnormal parameters is indicative of metabolic syndrome
This article was previously published October 18, 2020, and has been updated with new information.

While SARS-CoV-2 is a rampant virus that can cause severe problems in vulnerable individuals, the real pandemic — meaning the underlying cause that makes people susceptible to complications from the infection in the first place — is metabolic inflexibility or insulin resistance.

In this interview, Dr. Aseem Malhotra, a British cardiologist and author of "The 21 Day Immunity Plan," delves into the specifics and explains the role insulin resistance plays in the COVID-19 pandemic.

"The real pandemic is poor metabolic health, or metabolic inflexibility," Malhotra says. "I had become aware, as early on as March, when we were getting data from China and Italy, that there was a clear link between conditions related to excess body fat, in simple terms defined as poor metabolic health, [and] worse outcomes from COVID-19.

We're talking about conditions like Type 2 diabetes, high blood pressure, heart disease and, of course, obesity. And that data kept emerging. That link was so clear, and it wasn't just out of the blue.

As somebody who's been a practicing doctor for almost two decades, it's very clear — we know people who have poor metabolic health certainly tend to have worse outcomes from really any infection, but COVID-19 has highlighted it more, and made us think about it more.

We're talking about chest infections, hospital admissions with pneumonia [and] Type 2 diabetics tend to do a lot worse. I was looking at that data and thought, 'There's something missing out of this mainstream conversation.' It was getting a lot of immediate coverage across the world, in the U.K., in the United States, but no one was talking about lifestyle."

Obesity Is a Significant COVID-19 Risk Factor
Aside from old age, obesity has been identified as one of the primary risk factors for being hospitalized with COVID-19 — doubling the risk of hospitalization in patients under the age of 60 in one study1 — even if the individual has no other obesity-related health problems. A French study2,3 also found obese patients treated for COVID-19 were more likely to require mechanical ventilation.

One hypothesis for why obesity is worsening COVID-19 has to do with the fact that obesity causes chronic inflammation.4 Having more proinflammatory cytokines in circulation increases your risk of experiencing a cytokine storm.

A cytokine storm response is typically the reason why people die from infections, be it the seasonal flu, Ebola, urinary tract infection or COVID-19. Obesity also makes you more vulnerable to infectious diseases by lowering your immune function.5,6,7,8,9,10

Insulin Resistance Augments Infection Risks
Obesity is often rooted in insulin resistance, brought on by a flawed diet, and insulin resistance is another top risk factor for COVID-19 that worsens outcomes and increases your risk of death. An April 15, 2020, article11 in The Scientist reviews evidence12,13 showing how higher blood glucose levels impact viral replication and the development of cytokine storms.

While the research in question looked at influenza A-induced cytokine storms, these findings may well be applicable in COVID-19 as well. In a Science Advances press release, co-author Shi Liu stated:14

"We believe that glucose metabolism contributes to various COVID-19 outcomes since both influenza and COVID-19 can induce a cytokine storm, and since COVID-19 patients with diabetes have shown higher mortality."

COVID-19 Risk Factors Can Be Rapidly Ameliorated
The good news, as Malhotra stresses, is that the lifestyle factors that make you more prone to severe COVID-19 infection and death can be modified and ameliorated in as little as 21 days, simply by changing your diet....