The Douay–Rheims Bible (ˌduːeɪ ˈriːmz ), also known as the Douay–Rheims Version, Rheims–Douai Bible or Douai Bible, and abbreviated as D–R, DRB, and DRV, is a translation of the Bible from the Latin Vulgate into English made by members of the English College, Douai, in the service of the Catholic Church. The New Testament portion was published in Reims, France, in 1582, in one volume with extensive commentary and notes. The Old Testament portion was published in two volumes twenty-seven years later in 1609 and 1610 by the University of Douai. The first volume, covering Genesis to Job, was published in 1609; the second, covering the Book of Psalms to 2 Maccabees (spelt "Machabees") plus the three apocryphal books of the Vulgate appendix following the Old Testament (Prayer of Manasseh, 3 Esdras, and 4 Esdras), was published in 1610. Marginal notes took up the bulk of the volumes and offered insights on issues of translation, and on the Hebrew and Greek source texts of the Vulgate.

The Douay–Rheims Bible is a translation of the Latin Vulgate, which is itself a translation of Hebrew, Aramaic, and Greek texts. The Vulgate was largely created due to the efforts of Saint Jerome (345–420), whose translation was declared to be the authentic Latin version of the Bible by the Council of Trent.