NAC vs. Glutathione supplements - NAC works to raise GSH levels far better than oral glutathione supplements primarily because reduced glutathione is an endogenous antioxidant that is best produced by the body from raw materials: the amino acids L-cysteine, glutamic acid, and glycine. 2 of the 3, L-cysteine and glycine, are rate-limiting nutrients for GSH production. NAC, or N-acetyl-L-cysteine, provides your body with valuable L-cysteine to increase glutathione production. Glycine is also valuable in this equation. The body synthesizes GSH in a two-part process: 1) L-cysteine links with glutamic acid by means of glutamate cysteine ligase, resulting in gamma-glutamylcysteine (GGC); 2) glycine is attached by means of glutathione synthase. Research has shown that GGC converts to 5-L-oxoproline and is excreted in the urine when there is not enough glycine available to complete the transition to GSH.


Links:
N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044191/

Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855430/

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